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Endocannabinoid Control of Food Intake and Energy Balance

 
by Vincenzo Di Marzo & Isabel Matias; Nature Neuroscience  8, 585 - 589 (2005); Posted: 2005-07-15
[Identifier: http://www.doctordeluca.com/Library/AddictionMeds/Endocannabinoid&FoodEnergy05.htm]
  [Source: http://www.nature.com/neuro/journal/v8/n5/abs/nn1457.html]
 [Related resources: http://www.doctordeluca.com/Library/LibPages/PharmRx.htm]
[See also: “Medical Marijuana: the Pain of Prohibition”; Muwakkil; Common Dreams News Center; 2004-12-29]
 

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ABSTRACT

Marijuana and its major psychotropic component, ⁹-tetrahydrocannabinol, stimulate appetite and increase body weight in wasting syndromes, suggesting that the CB₁ cannabinoid receptor and its endogenous ligands, the endocannabinoids, are involved in controlling energy balance. The endocannabinoid system controls food intake via both central and peripheral mechanisms, and it may also stimulate lipogenesis and fat accumulation. Here we discuss the multifaceted regulation of energy homeostasis by endocannabinoids, together with its applications to the treatment of eating disorders and metabolic syndromes.

[Full Text of this Article in PDF/print format]

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