Chris Wright; Boston Magazine; July, 2006. Posted: 2006-07-09. Source
"'I’m curious to see what the results [of real world experience with Vivitrol] will be,' says DeLuca, 'Will there be increased abstinence or will there be reduced harmful drinking? I think the latter.'
"Harvard professor of psychiatry George Vaillant is appalled by that possibility... The science behind Vivitrol, he adds, represents little more than a futile attempt to exercise control over the uncontrollable... 'What we know about the neurobiology of alcoholism has no effect on the fact that it kills 100,000 Americans a year. Our improved neurological understanding is displacement. We’re comforting ourselves.'"
Author Wright does a pretty good job of explaining and tying together difficut and disparate issues including the 'disease concept' of alcoholism, the 'Abstinence vs. Harm Reduction Wars of Summer 2000
', the Vivitrol randomized controlled trial, and the issues and confusion provoked by the FDA indication that Vivitrol be used to promote abstinence.
The abstinence indication is in conflict with the research
in which about 90% of the patients drank during the 6 month study. The patients on Vivitrol had significantly less heavy drinking compared to patients who drank on placebo. This was the primary outcome of the study on which FDA based it's approval. Political Science
can get pretty convoluted. <smile>
Vivitrol for Alcohol Dependence - A Randomized, Controlled Trial
- Garbutt, Kranzler, O'Malley, Gastfriend, Pettinati, Silverman, Loewy, and Ehrich; JAMA; 293; 2005-04-06. Posted: 2006-01-08.
The Controlled Drinking Debates: Review of Four Decades of Acrimony
- Brook Hersey, Psy.D., Rutgers, 2001. Posted: 2002-10-11.
The Abstinence vs. Harm Reduction Follies of Summer 2000 - Addiction Medicine Shoots Self in Foot, Again
The Naltrexone (Trexan/Revia/Vivitrol) Collection arvhives